2025 Toyota Sienna 2WD MPG & Specs — Real Fuel Cost
Quick answer
The 2025 Toyota Sienna 2WD gets an EPA-estimated 36/36 MPG (city/highway) and 36 MPG combined, with an estimated $1,700/year fuel cost and 246 g/mi CO₂. Engine: 2.5 L 4-cyl.
The 2025 Toyota Sienna 2WD with the 2.5-liter 4-cylinder regular gasoline engine returns an EPA-estimated 36 MPG in the city and 36 MPG on the highway, for a combined 36 MPG. This page summarizes the official EPA fuel-economy and emissions data for this configuration.
| Engine | 2.5 L 4-cyl |
| Transmission | Automatic (AV-S6) |
| Drive | Front-Wheel Drive |
| Fuel type | Regular Gasoline |
| Vehicle class | Minivan - 2WD |
| MPG — city | 36 |
| MPG — highway | 36 |
| MPG — combined | 36 |
| Annual fuel cost* | $1,700 |
| CO₂ tailpipe | 246 g/mi |
| EPA GHG score | 7/10 |
How efficient is it?
With a combined 36 MPG, the 2025 Toyota Sienna 2WD sits in the very good range for fuel economy. That is about 77% better than the typical Minivan - 2WD of its era (20 MPG class average), making it one of the more efficient choices in its class.
Fuel economy and running costs
At about $1,700 per year in fuel (EPA estimate, 15,000 mi/yr), fuel is a major part of the cost of owning the 2025 Toyota Sienna 2WD. Over five years that is roughly $8,500 at today's prices — before insurance, maintenance, and depreciation.
Emissions
The 2025 Toyota Sienna 2WD emits approximately 246 grams of CO₂ per mile at the tailpipe, earning an EPA greenhouse-gas score of 7 out of 10. Lower emissions generally track higher fuel economy.
How to read these numbers
EPA figures come from standardized laboratory test cycles and are the same estimates shown on the vehicle's window sticker. Your real-world mileage depends on driving style, conditions, fuel grade, and maintenance. Use combined MPG and annual fuel cost to compare vehicles fairly.