2025 Mercedes-Benz S500 4matic MPG & Specs — Real Fuel Cost
Quick answer
The 2025 Mercedes-Benz S500 4matic gets an EPA-estimated 21/31 MPG (city/highway) and 24 MPG combined, with an estimated $3,150/year fuel cost and 364 g/mi CO₂. Engine: 3 L 6-cyl.
The 2025 Mercedes-Benz S500 4matic with the 3-liter 6-cylinder premium gasoline engine returns an EPA-estimated 21 MPG in the city and 31 MPG on the highway, for a combined 24 MPG. This page summarizes the official EPA fuel-economy and emissions data for this configuration.
| Engine | 3 L 6-cyl |
| Transmission | Automatic 9-spd |
| Drive | All-Wheel Drive |
| Fuel type | Premium Gasoline |
| Vehicle class | Large Cars |
| MPG — city | 21 |
| MPG — highway | 31 |
| MPG — combined | 24 |
| Annual fuel cost* | $3,150 |
| CO₂ tailpipe | 364 g/mi |
| EPA GHG score | 5/10 |
How efficient is it?
With a combined 24 MPG, the 2025 Mercedes-Benz S500 4matic sits in the moderate range for fuel economy. That is about average for its class (Large Cars, 26 MPG average).
Fuel economy and running costs
At about $3,150 per year in fuel (EPA estimate, 15,000 mi/yr), fuel is a major part of the cost of owning the 2025 Mercedes-Benz S500 4matic. Over five years that is roughly $15,750 at today's prices — before insurance, maintenance, and depreciation.
Emissions
The 2025 Mercedes-Benz S500 4matic emits approximately 364 grams of CO₂ per mile at the tailpipe, earning an EPA greenhouse-gas score of 5 out of 10. Lower emissions generally track higher fuel economy.
How to read these numbers
EPA figures come from standardized laboratory test cycles and are the same estimates shown on the vehicle's window sticker. Your real-world mileage depends on driving style, conditions, fuel grade, and maintenance. Use combined MPG and annual fuel cost to compare vehicles fairly.