2025 Mercedes-Benz GLS580 4matic MPG & Specs — Real Fuel Cost
Quick answer
The 2025 Mercedes-Benz GLS580 4matic gets an EPA-estimated 14/19 MPG (city/highway) and 16 MPG combined, with an estimated $4,750/year fuel cost and 548 g/mi CO₂. Engine: 4 L 8-cyl.
The 2025 Mercedes-Benz GLS580 4matic with the 4-liter 8-cylinder premium gasoline engine returns an EPA-estimated 14 MPG in the city and 19 MPG on the highway, for a combined 16 MPG. This page summarizes the official EPA fuel-economy and emissions data for this configuration.
| Engine | 4 L 8-cyl |
| Transmission | Automatic 9-spd |
| Drive | All-Wheel Drive |
| Fuel type | Premium Gasoline |
| Vehicle class | Standard Sport Utility Vehicle 4WD |
| MPG — city | 14 |
| MPG — highway | 19 |
| MPG — combined | 16 |
| Annual fuel cost* | $4,750 |
| CO₂ tailpipe | 548 g/mi |
| EPA GHG score | 3/10 |
How efficient is it?
With a combined 16 MPG, the 2025 Mercedes-Benz GLS580 4matic sits in the low range for fuel economy. That is roughly 47% thirstier than the typical Standard Sport Utility Vehicle 4WD of its era (30 MPG class average) — expect higher fuel bills than class-average alternatives.
Fuel economy and running costs
At about $4,750 per year in fuel (EPA estimate, 15,000 mi/yr), fuel is a major part of the cost of owning the 2025 Mercedes-Benz GLS580 4matic. Over five years that is roughly $23,750 at today's prices — before insurance, maintenance, and depreciation.
Emissions
The 2025 Mercedes-Benz GLS580 4matic emits approximately 548 grams of CO₂ per mile at the tailpipe, earning an EPA greenhouse-gas score of 3 out of 10. Lower emissions generally track higher fuel economy.
How to read these numbers
EPA figures come from standardized laboratory test cycles and are the same estimates shown on the vehicle's window sticker. Your real-world mileage depends on driving style, conditions, fuel grade, and maintenance. Use combined MPG and annual fuel cost to compare vehicles fairly.