2025 Lexus RX 450h Plus AWD MPG & Specs — Real Fuel Cost
Quick answer
The 2025 Lexus RX 450h Plus AWD gets an EPA-estimated 36/33 MPG (city/highway) and 35 MPG combined, with an estimated $2,150/year fuel cost and 89 g/mi CO₂. Engine: 2.5 L 4-cyl.
The 2025 Lexus RX 450h Plus AWD with the 2.5-liter 4-cylinder premium gasoline engine returns an EPA-estimated 36 MPG in the city and 33 MPG on the highway, for a combined 35 MPG. This page summarizes the official EPA fuel-economy and emissions data for this configuration.
| Engine | 2.5 L 4-cyl |
| Transmission | Automatic (AV-S6) |
| Drive | All-Wheel Drive |
| Fuel type | Premium Gasoline |
| Vehicle class | Small Sport Utility Vehicle 4WD |
| MPG — city | 36 |
| MPG — highway | 33 |
| MPG — combined | 35 |
| Annual fuel cost* | $2,150 |
| CO₂ tailpipe | 89 g/mi |
| EPA GHG score | 9/10 |
| Electric range | 540 mi |
How efficient is it?
With a combined 35 MPG, the 2025 Lexus RX 450h Plus AWD sits in the very good range for fuel economy. That is about 13% better than the typical Small Sport Utility Vehicle 4WD of its era (31 MPG class average), making it one of the more efficient choices in its class.
Fuel economy and running costs
At about $2,150 per year in fuel (EPA estimate, 15,000 mi/yr), fuel is a major part of the cost of owning the 2025 Lexus RX 450h Plus AWD. Over five years that is roughly $10,750 at today's prices — before insurance, maintenance, and depreciation.
Emissions
The 2025 Lexus RX 450h Plus AWD emits approximately 89 grams of CO₂ per mile at the tailpipe, earning an EPA greenhouse-gas score of 9 out of 10. Lower emissions generally track higher fuel economy.
How to read these numbers
EPA figures come from standardized laboratory test cycles and are the same estimates shown on the vehicle's window sticker. Your real-world mileage depends on driving style, conditions, fuel grade, and maintenance. Use combined MPG and annual fuel cost to compare vehicles fairly.