2022 Mercedes-Benz E450 4matic MPG & Specs — Real Fuel Cost
Quick answer
The 2022 Mercedes-Benz E450 4matic gets an EPA-estimated 23/30 MPG (city/highway) and 25 MPG combined, with an estimated $3,050/year fuel cost and 348 g/mi CO₂. Engine: 3 L 6-cyl.
The 2022 Mercedes-Benz E450 4matic with the 3-liter 6-cylinder premium gasoline engine returns an EPA-estimated 23 MPG in the city and 30 MPG on the highway, for a combined 25 MPG. This page summarizes the official EPA fuel-economy and emissions data for this configuration.
| Engine | 3 L 6-cyl |
| Transmission | Automatic 9-spd |
| Drive | 4-Wheel Drive |
| Fuel type | Premium Gasoline |
| Vehicle class | Midsize Cars |
| MPG — city | 23 |
| MPG — highway | 30 |
| MPG — combined | 25 |
| Annual fuel cost* | $3,050 |
| CO₂ tailpipe | 348 g/mi |
| EPA GHG score | 5/10 |
How efficient is it?
With a combined 25 MPG, the 2022 Mercedes-Benz E450 4matic sits in the moderate range for fuel economy. That is about average for its class (Midsize Cars, 26 MPG average).
Fuel economy and running costs
At about $3,050 per year in fuel (EPA estimate, 15,000 mi/yr), fuel is a major part of the cost of owning the 2022 Mercedes-Benz E450 4matic. Over five years that is roughly $15,250 at today's prices — before insurance, maintenance, and depreciation.
Emissions
The 2022 Mercedes-Benz E450 4matic emits approximately 348 grams of CO₂ per mile at the tailpipe, earning an EPA greenhouse-gas score of 5 out of 10. Lower emissions generally track higher fuel economy.
How to read these numbers
EPA figures come from standardized laboratory test cycles and are the same estimates shown on the vehicle's window sticker. Your real-world mileage depends on driving style, conditions, fuel grade, and maintenance. Use combined MPG and annual fuel cost to compare vehicles fairly.