2022 Lexus RX 450h L AWD MPG & Specs — Real Fuel Cost
Quick answer
The 2022 Lexus RX 450h L AWD gets an EPA-estimated 29/28 MPG (city/highway) and 29 MPG combined, with an estimated $2,600/year fuel cost and 305 g/mi CO₂. Engine: 3.5 L 6-cyl.
The 2022 Lexus RX 450h L AWD with the 3.5-liter 6-cylinder premium gasoline engine returns an EPA-estimated 29 MPG in the city and 28 MPG on the highway, for a combined 29 MPG. This page summarizes the official EPA fuel-economy and emissions data for this configuration.
| Engine | 3.5 L 6-cyl |
| Transmission | Automatic (AV-S6) |
| Drive | All-Wheel Drive |
| Fuel type | Premium Gasoline |
| Vehicle class | Standard Sport Utility Vehicle 4WD |
| MPG — city | 29 |
| MPG — highway | 28 |
| MPG — combined | 29 |
| Annual fuel cost* | $2,600 |
| CO₂ tailpipe | 305 g/mi |
| EPA GHG score | 6/10 |
How efficient is it?
With a combined 29 MPG, the 2022 Lexus RX 450h L AWD sits in the good range for fuel economy. That is about average for its class (Standard Sport Utility Vehicle 4WD, 30 MPG average).
Fuel economy and running costs
At about $2,600 per year in fuel (EPA estimate, 15,000 mi/yr), fuel is a major part of the cost of owning the 2022 Lexus RX 450h L AWD. Over five years that is roughly $13,000 at today's prices — before insurance, maintenance, and depreciation.
Emissions
The 2022 Lexus RX 450h L AWD emits approximately 305 grams of CO₂ per mile at the tailpipe, earning an EPA greenhouse-gas score of 6 out of 10. Lower emissions generally track higher fuel economy.
How to read these numbers
EPA figures come from standardized laboratory test cycles and are the same estimates shown on the vehicle's window sticker. Your real-world mileage depends on driving style, conditions, fuel grade, and maintenance. Use combined MPG and annual fuel cost to compare vehicles fairly.