2010 Mercedes-Benz ML450 Hybrid 4matic MPG & Specs — Real Fuel Cost
Quick answer
The 2010 Mercedes-Benz ML450 Hybrid 4matic gets an EPA-estimated 21/24 MPG (city/highway) and 22 MPG combined, with an estimated $3,450/year fuel cost and 403.955 g/mi CO₂. Engine: 3.5 L 6-cyl.
The 2010 Mercedes-Benz ML450 Hybrid 4matic with the 3.5-liter 6-cylinder premium gasoline engine returns an EPA-estimated 21 MPG in the city and 24 MPG on the highway, for a combined 22 MPG. This page summarizes the official EPA fuel-economy and emissions data for this configuration.
| Engine | 3.5 L 6-cyl |
| Transmission | Automatic (variable gear ratios) |
| Drive | 4-Wheel Drive |
| Fuel type | Premium Gasoline |
| Vehicle class | Sport Utility Vehicle - 4WD |
| MPG — city | 21 |
| MPG — highway | 24 |
| MPG — combined | 22 |
| Annual fuel cost* | $3,450 |
| CO₂ tailpipe | 403.955 g/mi |
| EPA GHG score | — |
How efficient is it?
With a combined 22 MPG, the 2010 Mercedes-Benz ML450 Hybrid 4matic sits in the moderate range for fuel economy. That is about 27% better than the typical Sport Utility Vehicle - 4WD of its era (17 MPG class average), making it one of the more efficient choices in its class.
Fuel economy and running costs
At about $3,450 per year in fuel (EPA estimate, 15,000 mi/yr), fuel is a major part of the cost of owning the 2010 Mercedes-Benz ML450 Hybrid 4matic. Over five years that is roughly $17,250 at today's prices — before insurance, maintenance, and depreciation.
Emissions
The 2010 Mercedes-Benz ML450 Hybrid 4matic emits approximately 403.955 grams of CO₂ per mile at the tailpipe. Lower emissions generally track higher fuel economy.
How to read these numbers
EPA figures come from standardized laboratory test cycles and are the same estimates shown on the vehicle's window sticker. Your real-world mileage depends on driving style, conditions, fuel grade, and maintenance. Use combined MPG and annual fuel cost to compare vehicles fairly.