2006 Mercedes-Benz S600 MPG & Specs — Real Fuel Cost
Quick answer
The 2006 Mercedes-Benz S600 gets an EPA-estimated 11/17 MPG (city/highway) and 13 MPG combined, with an estimated $5,850/year fuel cost and 683.615 g/mi CO₂. Engine: 5.5 L 12-cyl.
The 2006 Mercedes-Benz S600 with the 5.5-liter 12-cylinder premium gasoline engine returns an EPA-estimated 11 MPG in the city and 17 MPG on the highway, for a combined 13 MPG. This page summarizes the official EPA fuel-economy and emissions data for this configuration.
| Engine | 5.5 L 12-cyl |
| Transmission | Automatic 5-spd |
| Drive | Rear-Wheel Drive |
| Fuel type | Premium Gasoline |
| Vehicle class | Large Cars |
| MPG — city | 11 |
| MPG — highway | 17 |
| MPG — combined | 13 |
| Annual fuel cost* | $5,850 |
| CO₂ tailpipe | 683.615 g/mi |
| EPA GHG score | — |
How efficient is it?
With a combined 13 MPG, the 2006 Mercedes-Benz S600 sits in the low range for fuel economy. That is roughly 50% thirstier than the typical Large Cars of its era (26 MPG class average) — expect higher fuel bills than class-average alternatives.
Fuel economy and running costs
At about $5,850 per year in fuel (EPA estimate, 15,000 mi/yr), fuel is a major part of the cost of owning the 2006 Mercedes-Benz S600. Over five years that is roughly $29,250 at today's prices — before insurance, maintenance, and depreciation.
Emissions
The 2006 Mercedes-Benz S600 emits approximately 683.615 grams of CO₂ per mile at the tailpipe. Lower emissions generally track higher fuel economy.
How to read these numbers
EPA figures come from standardized laboratory test cycles and are the same estimates shown on the vehicle's window sticker. Your real-world mileage depends on driving style, conditions, fuel grade, and maintenance. Use combined MPG and annual fuel cost to compare vehicles fairly.